GON7/YJL184W Summary Help

Standard Name GON7 1
Systematic Name YJL184W
Alias LDB6 1 , PCC2 2
Feature Type ORF, Verified
Description Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; implicated in osmotic stress response; other complex members are Kae1p, Cgi121p, Pcc1p, and Bud32p (1, 2, 3, 4, 5, 6)
Chromosomal Location
ChrX:83448 to 83819 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GON7 GO evidence and references
  View Computational GO annotations for GON7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
40 total interaction(s) for 28 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Protein-peptide: 3
  • Two-hybrid: 11

Genetic Interactions
  • Negative Genetic: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 123
Molecular Weight (Da) 13,605
Isoelectric Point (pI) 4.55
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:83448 to 83819 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..372 83448..83819 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003720
References cited on this page View Complete Literature Guide for GON7
1) Corbacho I, et al.  (2004) Identification of low-dye-binding (ldb) mutants of Saccharomyces cerevisiae. FEMS Yeast Res 4(4-5):437-44
2) Kisseleva-Romanova E, et al.  (2006) Yeast homolog of a cancer-testis antigen defines a new transcription complex. EMBO J 25(15):3576-85
3) Garay-Arroyo A, et al.  (2000) Highly hydrophilic proteins in prokaryotes and eukaryotes are common during conditions of water deficit. J Biol Chem 275(8):5668-74
4) Downey M, et al.  (2006) A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell 124(6):1155-68
5) Srinivasan M, et al.  (2011) The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. EMBO J 30(5):873-81
6) Hu Y, et al.  (2013) Telomerase-null survivor screening identifies novel telomere recombination regulators. PLoS Genet 9(1):e1003208