Standard Name	PFD1
Systematic Name	YJL179W
Alias	GIM6
Feature Type	ORF, Verified
Description	Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin (1, 2)
Name Description	PreFolDin 1

Chromosomal Location	ChrX:88787 to 89116 | ORF Map | GBrowse

	View Computational GO annotations for PFD1
Molecular Function
Manually curated	unfolded protein binding (IMP, ISS)
Biological Process
Manually curated	cytoskeleton organization (IMP) protein folding (IMP, ISS)
Cellular Component
Manually curated	prefoldin complex (IMP, ISS)

Classical genetics
null	chromosome/plasmid maintenance: abnormal resistance to bortezomib: decreased resistance to benomyl: decreased
Large-scale survey
null	glycogen accumulation: increased competitive fitness: decreased heat sensitivity: increased resistance to ethanol: decreased resistance to benomyl: decreased resistance to streptomycin: decreased resistance to wortmannin: normal resistance to quinine: decreased resistance to sodium arsenite: decreased resistance to arsenite(3-): decreased resistance to hydroxyurea: decreased resistance to sirolimus: decreased resistance to cycloheximide: decreased stress resistance: increased telomere length: increased vegetative growth: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	306 total interaction(s) for 230 unique genes/features.
Physical Interactions	Affinity Capture-MS: 25 Affinity Capture-RNA: 3 Two-hybrid: 8
Genetic Interactions	Negative Genetic: 99 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Positive Genetic: 100 Synthetic Growth Defect: 13 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 43 Synthetic Rescue: 10
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:88787 to 89116 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..330 88787..89116 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003715