SSY5/YJL156C Summary Help

Standard Name SSY5 1
Systematic Name YJL156C
Alias RAA3 2
Feature Type ORF, Verified
Description Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p; other members are Ssy1p and Ptr3p (3, 4, 5, 6)
Name Description Sulfonylurea Sensitive on YPD 1
Chromosomal Location
ChrX:128952 to 126853 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All SSY5 GO evidence and references
  View Computational GO annotations for SSY5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Classical genetics
reduction of function
Large-scale survey
25 total interaction(s) for 12 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Rescue: 5
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 699
Molecular Weight (Da) 77,526
Isoelectric Point (pI) 6.42
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrX:128952 to 126853 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 2009-02-18
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2100 128952..126853 2011-02-03 2009-02-18
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003692
References cited on this page View Complete Literature Guide for SSY5
1) Jorgensen MU, et al.  (1998) Mutations in five loci affecting GAP1-independent uptake of neutral amino acids in yeast. Yeast 14(2):103-14
2) McCusker JH and Haber JE  (1990) Mutations in Saccharomyces cerevisiae which confer resistance to several amino acid analogs. Mol Cell Biol 10(6):2941-9
3) Forsberg H and Ljungdahl PO  (2001) Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids. Mol Cell Biol 21(3):814-26
4) Forsberg H, et al.  (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28
5) Poulsen P, et al.  (2006) Mapping of an internal protease cleavage site in the Ssy5p component of the amino acid sensor of Saccharomyces cerevisiae and functional characterization of the resulting pro- and protease domains by gain-of-function genetics. Eukaryot Cell 5(3):601-8
6) Andreasson C, et al.  (2006) Regulation of transcription factor latency by receptor-activated proteolysis. Genes Dev 20(12):1563-8