MTC1/YJL123C Summary Help

Standard Name MTC1 1
Systematic Name YJL123C
Feature Type ORF, Verified
Description Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 (1, 2, 3, 4)
Name Description Maintenance of Telomere Capping 1
Chromosomal Location
ChrX:189440 to 188004 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MTC1 GO evidence and references
  View Computational GO annotations for MTC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 1 genes
Resources
Large-scale survey
null
overexpression
Resources
157 total interaction(s) for 94 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 2
  • Negative Genetic: 97
  • Phenotypic Enhancement: 16
  • Phenotypic Suppression: 10
  • Positive Genetic: 5
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 478
Molecular Weight (Da) 53,477
Isoelectric Point (pI) 4.32
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:189440 to 188004 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1437 189440..188004 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003659
References cited on this page View Complete Literature Guide for MTC1
1) Addinall SG, et al.  (2008) A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae. Genetics 180(4):2251-66
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Fleischer TC, et al.  (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307