Standard Name	AIM22 1
Systematic Name	YJL046W
Alias	LIP3 2 , RRG3 3
Feature Type	ORF, Verified
Description	Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss (1, 2, 4, 5, 6)
Name Description	Altered Inheritance rate of Mitochondria 1

Chromosomal Location	ChrX:352386 to 353615 | ORF Map | GBrowse

	View Computational GO annotations for AIM22
Molecular Function
Manually curated	lipoate-protein ligase activity (ISA)
Biological Process
Manually curated	protein lipoylation (IMP)
Cellular Component
Manually curated	mitochondrion (IDA)

Classical genetics
null	lipoic acid accumulation: decreased Ptr2p-GFP distribution: abnormal Lat1p modification: absent Kgd2p modification: absent resistance to Calcofluor White: increased
Large-scale survey
null	cell size: decreased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased mitochondrial genome maintenance: abnormal nutrient utilization: decreased oxidative stress resistance: decreased resistance to benzo[a]pyrene: increased resistance to sorbate: decreased resistance to propolis extract: decreased resistance to benzo[a]pyrene: decreased resistance to acetic acid: decreased resistance to ethanol: decreased resistance to elesclomol-Cu: decreased resistance to hexadecylphosphocholine: increased resistance to zinc chloride: increased respiratory growth: absent respiratory growth: decreased rate stress resistance: increased toxin resistance: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	134 total interaction(s) for 97 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1
Genetic Interactions	Negative Genetic: 119 Phenotypic Enhancement: 1 Positive Genetic: 5 Synthetic Growth Defect: 4 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:352386 to 353615 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2005-12-01
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1230 352386..353615 2011-02-03 2005-12-01
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003582