Standard Name	MND2 1
Systematic Name	YIR025W
Feature Type	ORF, Verified
Description	Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase (1, 2, 3)
Name Description	Meiotic Nuclear Divisions 1

Chromosomal Location	ChrIX:403659 to 404765 | ORF Map | GBrowse

	View Computational GO annotations for MND2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (IPI) mitotic sister chromatid segregation (IMP) protein ubiquitination (IPI) reciprocal meiotic recombination (IMP) regulation of mitotic metaphase/anaphase transition (IMP)
Cellular Component
Manually curated	anaphase-promoting complex (IDA, IPI) nucleus (IDA)

Classical genetics
null	cell cycle passage through the metaphase-anaphase transition: delayed Clb5p accumulation: decreased sporulation: absent vegetative growth: decreased rate
reduction of function	Clb5p accumulation: decreased Clb5p accumulation: increased sporulation: decreased
Large-scale survey
null	competitive fitness: decreased meiosis: abnormal sporulation: decreased sporulation efficiency: decreased viable
overexpression	silencing: abnormal vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	109 total interaction(s) for 50 unique genes/features.
Physical Interactions	Affinity Capture-MS: 48 Affinity Capture-RNA: 2 Affinity Capture-Western: 8 Biochemical Activity: 1 PCA: 1 Two-hybrid: 4
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 27 Phenotypic Enhancement: 7 Phenotypic Suppression: 4 Synthetic Growth Defect: 3 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:403659 to 404765 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1107 403659..404765 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001464