Standard Name	DAL81
Systematic Name	YIR023W
Alias	UGA35
Feature Type	ORF, Verified
Description	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism (1, 2)
Name Description	Degradation of Allantoin

Chromosomal Location	ChrIX:399777 to 402689 | ORF Map | GBrowse
	Genetic position: 22 cM

	View Computational GO annotations for DAL81
Molecular Function
Manually curated	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly (IDA, IMP) RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription (IMP, IPI) RNA polymerase II transcription factor recruiting transcription factor activity (IDA, IMP)
Biological Process
Manually curated	nitrogen catabolite activation of transcription from RNA polymerase II promoter (IMP, IPI) positive regulation of gamma-aminobutyric acid catabolic process (IMP) positive regulation of urea catabolic process (IMP)
Cellular Component
Manually curated	nucleus (IC)

Binding motifs	Predicted DAL81 Binding Site Locations
	GAAAATTGCGTTT 3 [Search intergenic regions for GAAAATTGCGTTT]
Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
null	PTR2 mRNA accumulation: decreased tellurium atom accumulation: decreased Ptr2p-GFP accumulation: decreased resistance to 6-azauracil: decreased resistance to canavanine: decreased resistance to tunicamycin: decreased resistance to mercaptoethanol: decreased resistance to L-1,4-dithiothreitol: normal resistance to tellurite: increased small molecule transport: decreased utilization of nitrogen source: decreased
Large-scale survey
null	acid pH resistance: decreased alkaline pH resistance: decreased competitive fitness: decreased endocytosis: decreased filamentous growth: decreased haploinsufficient invasive growth: absent nutrient utilization: decreased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to nickel sulfate: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to streptomycin: decreased resistance to cadmium dichloride: decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to cycloheximide: increased resistance to caffeine: increased resistance to mycophenolic acid: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to formaldehyde: decreased resistance to acetic acid: decreased resistance to methyl methanesulfonate: decreased resistance to bleomycin: decreased resistance to hydroxyurea: decreased resistance to tunicamycin: decreased resistance to boric acid: decreased resistance to fluconazole: increased resistance to doxorubicin: decreased resistance to benzo[a]pyrene: decreased toxin resistance: increased toxin resistance: decreased viable
overexpression	filamentous growth: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	94 total interaction(s) for 87 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Biochemical Activity: 1 Co-localization: 1 Two-hybrid: 4
Genetic Interactions	Negative Genetic: 50 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 14 Synthetic Growth Defect: 14 Synthetic Lethality: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:399777 to 402689 | ORF Map | GBrowse
	Genetic position: 22 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2913 399777..402689 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001462