Standard Name	MRS1 1
Systematic Name	YIR021W
Alias	PET157
Feature Type	ORF, Verified
Description	Splicing protein; required for splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA; MRS1 has a paralog, CCE1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Mitochondrial RNA Splicing 1

Chromosomal Location	ChrIX:397294 to 398385 | ORF Map | GBrowse

	View Computational GO annotations for MRS1
Molecular Function
Manually curated	NOT endodeoxyribonuclease activity (IDA, ISS) RNA binding (IDA)
Biological Process
Manually curated	Group I intron splicing (IDA)
Cellular Component
High-throughput	mitochondrion (IDA)

Classical genetics
null	respiratory growth: absent
reduction of function	respiratory growth: absent
Large-scale survey
null	alkaline pH resistance: decreased glycogen accumulation: decreased glutathione excretion: increased dessication resistance: decreased endocytosis: decreased haploinsufficient resistance to sirolimus: decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to CTBT: decreased resistance to propolis extract: decreased resistance to wortmannin: normal resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to elesclomol-Cu: decreased resistance to tacrolimus (anhydrous) and tunicamycin: increased respiratory growth: absent respiratory growth: decreased rate sporulation efficiency: decreased transposable element transposition: increased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	23 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Protein-RNA: 2 Reconstituted Complex: 2
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 8 Phenotypic Suppression: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:397294 to 398385 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1092 397294..398385 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001460