Standard Name	MSL1 (see Nomenclature conflict Note)
Systematic Name	YIR009W
Alias	YIB9
Feature Type	ORF, Verified
Description	U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members (1, 2, 3) Also known as: YIB9w
Name Description	MUD Synthetic Lethal 2

Chromosomal Location	ChrIX:374525 to 374860 | ORF Map | GBrowse

	View Computational GO annotations for MSL1
Molecular Function
Manually curated	U2 snRNA binding (IPI)
Biological Process
Manually curated	mRNA splicing, via spliceosome (IMP, IPI, ISS)
Cellular Component
Manually curated	U2 snRNP (TAS) U2-type prespliceosome (IDA)

Classical genetics
null	heat sensitivity: increased
Large-scale survey
null	anaerobic growth: decreased competitive fitness: decreased competitive fitness: increased dessication resistance: decreased endocytosis: decreased haploinsufficient heat sensitivity: increased metal resistance: increased respiratory growth: decreased rate starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	88 total interaction(s) for 70 unique genes/features.
Physical Interactions	Affinity Capture-MS: 28 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Co-purification: 1 Reconstituted Complex: 1 Two-hybrid: 21
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 3 Negative Genetic: 7 Synthetic Growth Defect: 11 Synthetic Lethality: 10 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:374525 to 374860 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..336 374525..374860 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001448