CSM2/YIL132C Summary Help

Standard Name CSM2 1
Systematic Name YIL132C
Feature Type ORF, Verified
Description Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Shu1, Shu2, and promotes error-free DNA repair,; Shu complex mediates inhibition of Srs2p function; promotes formation of Rad51p filaments; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis (1, 2, 3, 4, 5, 6)
Name Description Chromosome Segregation in Meiosis 1
Chromosomal Location
ChrIX:100501 to 99860 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CSM2 GO evidence and references
  View Computational GO annotations for CSM2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
null
Large-scale survey
null
Resources
69 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Co-crystal Structure: 2
  • Co-purification: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 13

Genetic Interactions
  • Negative Genetic: 31
  • Phenotypic Suppression: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 7
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 213
Molecular Weight (Da) 24,952
Isoelectric Point (pI) 8.61
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:100501 to 99860 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..642 100501..99860 1994-12-10 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001394
References cited on this page View Complete Literature Guide for CSM2
1) Rabitsch KP, et al.  (2001) A screen for genes required for meiosis and spore formation based on whole-genome expression. Curr Biol 11(13):1001-9
2) Mankouri HW, et al.  (2007) Shu proteins promote the formation of homologous recombination intermediates that are processed by sgs1-rmi1-top3. Mol Biol Cell 18(10):4062-73
3) Ball LG, et al.  (2009) The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol 73(1):89-102
4) Bernstein KA, et al.  (2011) The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase. Mol Biol Cell 22(9):1599-607
5) Tao Y, et al.  (2012) Structural analysis of Shu proteins reveals a DNA binding role essential for resisting damage. J Biol Chem 287(24):20231-9
6) Sasanuma H, et al.  (2013) A new protein complex promoting the assembly of Rad51 filaments. Nat Commun 4():1676