POG1/YIL122W Summary Help

Standard Name POG1 1
Systematic Name YIL122W
Feature Type ORF, Verified
Description Nuclear chromatin-associated protein of unknown function; may have a role in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest and suppresses the stress sensitivity caused by a mutation in the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cycle-related genes; phsosphoylated form may be ubiquitinated by Dma2p; potential Cdc28p substrate; SBF regulated (1, 2, 3, 4, 5)
Name Description Promoter Of Growth 1
Chromosomal Location
ChrIX:130610 to 131665 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All POG1 GO evidence and references
  View Computational GO annotations for POG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 9 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
unspecified
Resources
46 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 4
  • Biochemical Activity: 1
  • Protein-peptide: 1
  • Protein-RNA: 1
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Growth Defect: 5
  • Dosage Rescue: 2
  • Negative Genetic: 16
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 351
Molecular Weight (Da) 39,498
Isoelectric Point (pI) 9.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:130610 to 131665 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1056 130610..131665 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001384
References cited on this page View Complete Literature Guide for POG1
1) Leza MA and Elion EA  (1999) POG1, a novel yeast gene, promotes recovery from pheromone arrest via the G1 cyclin CLN2. Genetics 151(2):531-43
2) Horak CE, et al.  (2002) Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Genes Dev 16(23):3017-33
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4) Demae M, et al.  (2007) Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses the stress sensitivity caused by the rsp5 mutation in Saccharomyces cerevisiae. FEMS Microbiol Lett 277(1):70-8
5) Oshiro S and Takagi H  (2014) The transcriptional activator Pog1 controls cell cycle, and its phosphorylated form is downregulated by the ubiquitin ligase Dma2 in Saccharomyces cerevisiae.LID - 10.1111/1567-1364.12190 [doi] FEMS Yeast Res ()