RPI1/YIL119C Summary Help

Standard Name RPI1 1
Systematic Name YIL119C
Feature Type ORF, Verified
Description Transcription factor, allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF (1, 2, 3, 4)
Name Description Ras-cAMP Pathway Inhibitor 1
Chromosomal Location
ChrIX:137877 to 136654 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RPI1 GO evidence and references
  View Computational GO annotations for RPI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 14 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
53 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 7
  • Negative Genetic: 35
  • Phenotypic Enhancement: 2
  • Positive Genetic: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 407
Molecular Weight (Da) 46,622
Isoelectric Point (pI) 9.83
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:137877 to 136654 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1224 137877..136654 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001381
References cited on this page View Complete Literature Guide for RPI1
1) Kim JH and Powers S  (1991) Overexpression of RPI1, a novel inhibitor of the yeast Ras-cyclic AMP pathway, down-regulates normal but not mutationally activated ras function. Mol Cell Biol 11(8):3894-904
2) Sobering AK, et al.  (2002) Yeast Rpi1 is a putative transcriptional regulator that contributes to preparation for stationary phase. Eukaryot Cell 1(1):56-65
3) Puria R, et al.  (2009) Critical role of RPI1 in the stress tolerance of yeast during ethanolic fermentation. FEMS Yeast Res 9(8):1161-71
4) Chin BL, et al.  (2012) Genetic variation in Saccharomyces cerevisiae: circuit diversification in a signal transduction network. Genetics 192(4):1523-32