MOB1/YIL106W Summary Help

Standard Name MOB1 1
Systematic Name YIL106W
Feature Type ORF, Verified
Description Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress (1, 2, 3, 4, 5, 6)
Name Description Mps One Binder 1
Chromosomal Location
ChrIX:166415 to 167444 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MOB1 GO evidence and references
  View Computational GO annotations for MOB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
repressible
Resources
99 total interaction(s) for 69 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 27
  • Affinity Capture-Western: 8
  • Biochemical Activity: 7
  • Co-crystal Structure: 1
  • Co-localization: 5
  • PCA: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 9

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 4
  • Dosage Rescue: 3
  • Negative Genetic: 10
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 9
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 314
Molecular Weight (Da) 35,882
Isoelectric Point (pI) 6.57
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:166415 to 167444 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1999-11-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..20 166415..166434 2011-02-03 1999-11-17
Intron 21..105 166435..166519 2011-02-03 1999-11-17
CDS 106..1030 166520..167444 2011-02-03 1999-11-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001368
References cited on this page View Complete Literature Guide for MOB1
1) Luca FC and Winey M  (1998) MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Mol Biol Cell 9(1):29-46
2) Komarnitsky SI, et al.  (1998) DBF2 protein kinase binds to and acts through the cell cycle-regulated MOB1 protein. Mol Cell Biol 18(4):2100-7
3) Yoshida S and Toh-e A  (2001) Regulation of the localization of Dbf2 and mob1 during cell division of saccharomyces cerevisiae. Genes Genet Syst 76(2):141-7
4) Mah AS, et al.  (2001) Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex. Proc Natl Acad Sci U S A 98(13):7325-30
5) Luca FC, et al.  (2001) Saccharomyces cerevisiae Mob1p is required for cytokinesis and mitotic exit. Mol Cell Biol 21(20):6972-83
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76