SEC28/YIL076W Summary Help

Standard Name SEC28
Systematic Name YIL076W
Alias ANU2
Feature Type ORF, Verified
Description Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress (1, 2)
Name Description SECretory
Chromosomal Location
ChrIX:216658 to 217548 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SEC28 GO evidence and references
  View Computational GO annotations for SEC28
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 99 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
618 total interaction(s) for 339 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 70
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 5
  • Co-crystal Structure: 2
  • Protein-peptide: 3
  • Reconstituted Complex: 3
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 418
  • Phenotypic Suppression: 2
  • Positive Genetic: 86
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 12
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 296
Molecular Weight (Da) 33,829
Isoelectric Point (pI) 4.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:216658 to 217548 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2005-11-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..891 216658..217548 2011-02-03 2005-11-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001338
References cited on this page View Complete Literature Guide for SEC28
1) Duden R, et al.  (1998) epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP. EMBO J 17(4):985-95
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76