FIS1/YIL065C Summary Help

FIS1 BASIC INFORMATION

Standard Name FIS1
Systematic Name YIL065C
Alias MDV2
Feature Type ORF, Verified
Description Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation (1, 2, 3)
Name Description mitochondrial FISsion
GO Annotations All FIS1 GO evidence and references
    View Computational GO annotations for FIS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All FIS1 Phenotype details and references
Classical genetics
null
overexpression
reduction of function
Large-scale survey
null
overexpression
Interactions FIS1 All interactions details and references
  View additional details at BioGRID
113 total interaction(s) for 80 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-Western: 7
  • Co-crystal Structure: 2
  • Co-localization: 4
  • PCA: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 15
Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 61
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 2
  • Positive Genetic: 6
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 3
Sequence Information
ChrIX:241772 to 241305 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..468 241772..241305 1994-12-10 1994-12-10
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001327

FIS1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for FIS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FIS1]

1) Mozdy AD, et al.  (2000) Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol 151(2):367-80
2) Kuravi K, et al.  (2006) Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. J Cell Sci 119(Pt 19):3994-4001
3) Kitagaki H, et al.  (2007) Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway. FEBS Lett 581(16):2935-42