Standard Name	CST6 1
Systematic Name	YIL036W
Alias	ACA2 2 , SHF1 3
Feature Type	ORF, Verified
Description	Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication (1, 2, 4, 5, 6)
Name Description	Chromosome STability 1

Chromosomal Location	ChrIX:285666 to 287429 | ORF Map | GBrowse

	View Computational GO annotations for CST6
Molecular Function
Manually curated	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA) sequence-specific DNA binding (IDA)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	cellular response to carbon dioxide (IMP) cellular response to oleic acid (IMP) DNA metabolic process (IMP) positive regulation of transcription from RNA polymerase II promoter (IDA) positive regulation of transcription from RNA polymerase II promoter by oleic acid (IMP)
Cellular Component
Manually curated	nucleus (IC)

Binding motifs	RTGACGTH 7 [Search intergenic regions for RTGACGTH]
Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
null	glutathione accumulation: increased cold sensitivity: increased resistance to benomyl: increased vegetative growth: decreased
overexpression	colony sectoring: increased mitotic recombination: increased resistance to hydroxyurea: decreased
unspecified	POT1 mRNA accumulation: increased
Large-scale survey
null	auxotrophy competitive fitness: decreased heat sensitivity: increased resistance to benzo[a]pyrene: increased resistance to sirolimus: decreased resistance to wortmannin: decreased resistance to hydroxyurea: decreased resistance to propolis extract: decreased resistance to quinine: decreased respiratory growth: decreased rate respiratory growth: absent stress resistance: decreased telomere length: decreased toxin resistance: increased transposable element transposition: decreased vacuolar morphology: abnormal viable
overexpression	cell cycle progression: abnormal colony sectoring: increased vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	58 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 2 Biochemical Activity: 1 PCA: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 21 Phenotypic Suppression: 1 Positive Genetic: 12 Synthetic Growth Defect: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:285666 to 287429 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1764 285666..287429 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001298