Standard Name	CKA1
Systematic Name	YIL035C
Feature Type	ORF, Verified
Description	Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching (1, 2, 3, 4, 5)
Name Description	Casein Kinase Alpha subunit
Gene Product Alias	CK2 subunit 1

Chromosomal Location	ChrIX:288908 to 287790 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -29 cM

	View Computational GO annotations for CKA1
Molecular Function
Manually curated	protein serine/threonine kinase activity (IDA)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	donor selection (IGI) protein phosphorylation (IDA, IMP) regulation of transcription from RNA polymerase I promoter (IDA) regulation of transcription from RNA polymerase III promoter (IDA) response to DNA damage stimulus (IDA)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	protein kinase CK2 complex (IDA) UTP-C complex (IDA)

Regulatory modules	predicted: stressResponse (487)

Classical genetics
null	cold sensitivity: increased ionic stress resistance: decreased metal resistance: increased resistance to tellurite: decreased
unspecified	transposable element transposition: decreased
Large-scale survey
null	competitive fitness: decreased resistance to methyl methanesulfonate: decreased resistance to dimethyl sulfoxide: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to camptothecin: decreased resistance to bleomycin: decreased resistance to citric acid: decreased resistance to tunicamycin: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	393 total interaction(s) for 256 unique genes/features.
Physical Interactions	Affinity Capture-MS: 210 Affinity Capture-RNA: 2 Affinity Capture-Western: 8 Biochemical Activity: 43 Co-purification: 3 PCA: 3 Reconstituted Complex: 7 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 10 Dosage Rescue: 5 Negative Genetic: 75 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 12 Synthetic Growth Defect: 7 Synthetic Lethality: 2 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:288908 to 287790 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -29 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1119 288908..287790 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001297