ARP1/YHR129C Summary Help

Standard Name ARP1 1
Systematic Name YHR129C
Alias ACT5 2
Feature Type ORF, Verified
Description Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin (2, 3, 4)
Name Description Actin-Related Protein
Chromosomal Location
ChrVIII:364153 to 362999 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ARP1 GO evidence and references
  View Computational GO annotations for ARP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
null
Large-scale survey
null
overexpression
Resources
401 total interaction(s) for 263 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 11
  • Co-fractionation: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 15

Genetic Interactions
  • Negative Genetic: 129
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 28
  • Synthetic Growth Defect: 32
  • Synthetic Lethality: 179

Resources
Expression Summary
histogram
Resources
Length (a.a.) 384
Molecular Weight (Da) 42,995
Isoelectric Point (pI) 5.26
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:364153 to 362999 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1155 364153..362999 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001171
References cited on this page View Complete Literature Guide for ARP1
1) Poch O and Winsor B  (1997) Who's who among the Saccharomyces cerevisiae actin-related proteins? A classification and nomenclature proposal for a large family. Yeast 13(11):1053-8
2) Muhua L, et al.  (1994) A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration. Cell 78(4):669-79
3) Clark SW and Meyer DI  (1994) ACT3: a putative centractin homologue in S. cerevisiae is required for proper orientation of the mitotic spindle. J Cell Biol 127(1):129-38
4) Igarashi R, et al.  (2005) Molecular dissection of ARP1 regions required for nuclear migration and cell wall integrity checkpoint functions in Saccharomyces cerevisiae. Cell Struct Funct 30(2):57-67