Standard Name	BZZ1 1
Systematic Name	YHR114W
Alias	LSB7 2
Feature Type	ORF, Verified
Description	SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins (2)

Chromosomal Location	ChrVIII:338083 to 339984 | ORF Map | GBrowse

	View Computational GO annotations for BZZ1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	actin filament organization (IPI) endocytosis (IGI) response to salt stress (IGI, IPI)
Cellular Component
Manually curated	actin cortical patch (IDA)
High-throughput	cytoplasm (IDA) mating projection tip (IDA)

Classical genetics
null	endocytosis: decreased
Large-scale survey
null	competitive fitness: increased endocytosis: decreased resistance to streptomycin: decreased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	161 total interaction(s) for 122 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 2 Affinity Capture-Western: 4 Biochemical Activity: 3 PCA: 2 Protein-peptide: 1 Reconstituted Complex: 1 Two-hybrid: 99
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Negative Genetic: 23 Phenotypic Enhancement: 4 Positive Genetic: 4 Synthetic Growth Defect: 6 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:338083 to 339984 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1902 338083..339984 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001156