Standard Name	KSP1
Systematic Name	YHR082C
Feature Type	ORF, Verified
Description	Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5)

Chromosomal Location	ChrVIII:271548 to 268459 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for KSP1
Molecular Function
Manually curated	protein serine/threonine kinase activity (ISA)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	cellular protein localization (IMP) negative regulation of macroautophagy (IGI, IMP) protein phosphorylation (ISA) regulation of filamentous growth (IMP) regulation of pseudohyphal growth (IMP) TOR signaling cascade (IMP, IPI)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)
High-throughput	cytoplasm (IDA)

Regulatory modules	predicted: stressResponse (541, 403) predicted: cellcycle (335) predicted: stressResponse (541, 403) predicted: cellcycle (335)

Classical genetics
null	autophagy: increased dessication resistance: decreased filamentous growth: decreased Bcy1p-vYFP distribution: abnormal Fus3p-vYFP distribution: abnormal Sks1p-vYFP distribution: abnormal pseudohyphal growth: decreased resistance to sirolimus: increased
reduction of function	Fus3p-vYFP distribution: abnormal Bcy1p-vYFP distribution: abnormal Sks1p-vYFP distribution: abnormal
unspecified	filamentous growth: decreased transposable element transposition: decreased
Large-scale survey
null	anaerobic growth: decreased competitive fitness: normal competitive fitness: decreased dessication resistance: decreased endocytosis: decreased resistance to streptomycin: decreased resistance to cycloheximide: decreased resistance to bleomycin: increased resistance to cycloheximide: increased resistance to caffeine: increased resistance to fenpropimorph: increased resistance to fluconazole: increased resistance to hydroxyurea: increased resistance to tunicamycin: increased resistance to arsenite(3-): decreased resistance to camptothecin: decreased resistance to L-1,4-dithiothreitol: decreased sporulation efficiency: increased vacuolar morphology: abnormal viable
overexpression	inviable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	414 total interaction(s) for 391 unique genes/features.
Physical Interactions	Affinity Capture-MS: 28 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 190 Protein-RNA: 1 Reconstituted Complex: 10 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 13 Dosage Lethality: 3 Dosage Rescue: 1 Negative Genetic: 151 Phenotypic Suppression: 2 Positive Genetic: 7 Synthetic Growth Defect: 1 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:271548 to 268459 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3090 271548..268459 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001124