PTC7/YHR076W Summary Help

Standard Name PTC7 1
Systematic Name YHR076W
Feature Type ORF, Verified
Description Type 2C serine/threonine protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; activates coenzyme Q6 biosynthesis by dephosphorylation of demethoxy-Q6 hydroxylase Coq7p (1, 2, 3, 4, 5, 6)
Name Description Phosphatase type Two C 1
Chromosomal Location
ChrVIII:251101 to 252225 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PTC7 GO evidence and references
  View Computational GO annotations for PTC7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
null
Large-scale survey
null
overexpression
Resources
38 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 3
  • Co-purification: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 3
  • Negative Genetic: 8
  • Positive Genetic: 5
  • Synthetic Growth Defect: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 343
Molecular Weight (Da) 37,782
Isoelectric Point (pI) 6.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:251101 to 252225 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..55 251101..251155 2011-02-03 2007-07-09
Intron 56..148 251156..251248 2011-02-03 2007-07-09
CDS 149..1125 251249..252225 2011-02-03 2007-07-09
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001118
References cited on this page View Complete Literature Guide for PTC7
1) Jiang L, et al.  (2002) The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeast. FEBS Lett 527(1-3):323-5
2) Ramos CW, et al.  (2000) Molecular analysis of the Saccharomyces cerevisiae YHR076w gene. IUBMB Life 50(6):371-7
3) Runner VM and Brewster JL  (2003) A genetic screen for yeast genes induced by sustained osmotic stress. Yeast 20(10):913-20
4) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
5) Juneau K, et al.  (2009) Alternative splicing of PTC7 in Saccharomyces cerevisiae determines protein localization. Genetics 183(1):185-94
6) Martin-Montalvo A, et al.  (2013) The phosphatase ptc7 induces coenzyme q biosynthesis by activating the hydroxylase coq7 in yeast. J Biol Chem 288(39):28126-37