Standard Name	RRM3 1
Systematic Name	YHR031C
Alias	RTT104
Feature Type	ORF, Verified
Description	DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p (2, 3)
Name Description	rDNA Recombination Mutation

Chromosomal Location	ChrVIII:172970 to 170799 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RRM3
Molecular Function
Manually curated	ATP-dependent DNA helicase activity (IDA) DNA helicase activity (IMP, ISS)
Biological Process
Manually curated	DNA replication (IGI, IMP, IPI) mitochondrial genome maintenance (IGI) replication fork progression beyond termination site (IMP)
Cellular Component
Manually curated	nuclear telomeric heterochromatin (IPI) replication fork (IDA, IMP)

Classical genetics
null	chromosome/plasmid maintenance: abnormal Myc-Sml1p accumulation: decreased GFP-Rad52p distribution: increased GFP-Rap1 distribution: abnormal Rad53p modification: increased resistance to hydroxyurea: decreased telomere length: increased transposable element transposition: increased viable
overexpression	budding: abnormal budding index: abnormal cell cycle progression in S phase: abnormal cellular morphology: abnormal
Large-scale survey
null	anaerobic growth: decreased bud morphology: abnormal competitive fitness: decreased hyperosmotic stress resistance: decreased mitotic recombination: increased Hta1p-GFP accumulation: decreased Rad52-YFP distribution: increased resistance to wortmannin: increased resistance to bleomycin: increased resistance to cycloheximide: increased resistance to sirolimus: decreased resistance to sulfanilamide: decreased resistance to camptothecin: decreased resistance to BPS: decreased resistance to hydroxyurea: increased resistance to streptomycin: decreased resistance to cycloheximide: decreased stress resistance: decreased transposable element transposition: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	322 total interaction(s) for 152 unique genes/features.
Physical Interactions	Affinity Capture-Western: 2 Biochemical Activity: 1 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Negative Genetic: 139 Phenotypic Enhancement: 22 Phenotypic Suppression: 17 Positive Genetic: 25 Synthetic Growth Defect: 48 Synthetic Lethality: 59 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:172970 to 170799 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2172 172970..170799 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001073