Standard Name	THR1 1
Systematic Name	YHR025W
Feature Type	ORF, Verified
Description	Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway (2, 3)
Name Description	THReonine requiring

Chromosomal Location	ChrVIII:159438 to 160511 | ORF Map | GBrowse
	Genetic position: 26 cM

	View Computational GO annotations for THR1
Molecular Function
Manually curated	homoserine kinase activity (IDA, ISS)
Biological Process
Manually curated	homoserine metabolic process (IDA) isoleucine metabolic process (TAS) methionine metabolic process (TAS) threonine biosynthetic process (IMP)
Cellular Component
Manually curated	cellular_component unknown (ND)

Pathways	superpathway of threonine and methionine biosynthesis superpathway of threonine biosynthesis threonine biosynthesis

Classical genetics
null	UV resistance: decreased alkaline pH resistance: decreased auxotrophy tellurium atom accumulation: decreased cold sensitivity: increased gamma ray resistance: decreased heat sensitivity: increased ionic stress resistance: decreased resistance to homoserine: decreased resistance to amitrole: decreased resistance to tellurite: increased resistance to DFD-VI-15: decreased resistance to mycophenolic acid: decreased resistance to hydroxyurea: decreased
Large-scale survey
null	UV resistance: decreased acid pH resistance: decreased polyphosphate accumulation: abnormal competitive fitness: decreased gamma ray resistance: decreased haploproficient ionic stress resistance: decreased petite-negative resistance to propolis extract: decreased resistance to hydrogen chloride: decreased resistance to (S)-lactic acid: decreased resistance to sirolimus: decreased resistance to caffeine: decreased resistance to acetaldehyde: decreased resistance to hydroxyurea: decreased resistance to doxorubicin: decreased resistance to mycophenolic acid: decreased resistance to citric acid: decreased resistance to tunicamycin: increased resistance to hydroxyurea: increased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to bleomycin: increased resistance to sorbate: decreased resistance to methyl methanesulfonate: decreased resistance to pentachlorophenol: decreased resistance to cycloheximide: decreased resistance to sodium selenide: decreased respiratory growth: decreased rate starvation resistance: decreased toxin resistance: increased toxin resistance: decreased utilization of nitrogen source: absent vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	108 total interaction(s) for 100 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 3 Affinity Capture-Western: 1 PCA: 2 Two-hybrid: 5
Genetic Interactions	Dosage Rescue: 6 Negative Genetic: 34 Positive Genetic: 20 Synthetic Growth Defect: 8 Synthetic Lethality: 12 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:159438 to 160511 | ORF Map | GBrowse
	Genetic position: 26 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1074 159438..160511 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001067