Standard Name	SPO13 1
Systematic Name	YHR014W
Feature Type	ORF, Verified
Description	Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II (2, 3)
Name Description	SPOrulation 4

Chromosomal Location	ChrVIII:132047 to 132922 | ORF Map | GBrowse
	Genetic position: 11 cM

	View Computational GO annotations for SPO13
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	meiotic sister chromatid cohesion (IGI, IMP, IPI) positive regulation of sister chromatid cohesion (IGI, IPI) protein localization to chromosome, centromeric region (IMP)
Cellular Component
Manually curated	condensed nuclear chromosome, centromeric region (IDA) nucleus (IDA)

Classical genetics
null	Sgo1p distribution: abnormal resistance to (-)-anisomycin: increased resistance to trichothecene: increased resistance to chloramphenicol: increased toxin resistance: increased
overexpression	budding: abnormal cell cycle progression in G2 phase: abnormal cell size: increased nuclear morphology: abnormal
reduction of function	sporulation: abnormal
Large-scale survey
null	competitive fitness: increased haploinsufficient sporulation: decreased vacuolar morphology: abnormal viable
overexpression	cell cycle progression: abnormal inviable vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	73 total interaction(s) for 54 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 1 Biochemical Activity: 3 Co-localization: 1 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 5 Phenotypic Enhancement: 11 Phenotypic Suppression: 8 Synthetic Lethality: 9 Synthetic Rescue: 28
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:132047 to 132922 | ORF Map | GBrowse
	Genetic position: 11 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..876 132047..132922 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001056