YHP1/YDR451C Summary

YHP1 BASIC INFORMATION

Standard Name	YHP1
Systematic Name	YDR451C
Feature Type	ORF, Verified
Description	One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval (1, 2)
Name Description	Yeast Homeo-Protein 3

GO Annotations	All YHP1 GO evidence and references
	View Computational GO annotations for YHP1
Molecular Function
Manually curated	DNA binding (IDA) specific transcriptional repressor activity (IDA, IGI, IPI)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter (IDA, IEP, IGI, IPI) regulation of meiosis (IEP, IPI) regulation of mitotic cell cycle (IMP)
Cellular Component
Manually curated	nuclear chromatin (IDA) nuclear chromosome (IDA)

Regulatory Role
Binding motifs	YHP1 Transcription Factor Binding Sites and References
	TAATTG
Regulatory modules	predicted: stressResponse ( 529 ) predicted: cellcycle ( 329 ) predicted: stressResponse ( 529 ) predicted: cellcycle ( 329 )

Mutant Phenotype	All YHP1 Phenotype details and references
Classical genetics
overexpression	actin cytoskeleton morphology: abnormal budding: abnormal cellular morphology: abnormal
Large-scale survey
null	competitive fitness: decreased viable
overexpression	vegetative growth: decreased

Interactions	YHP1 All interactions details and references
	25 total interaction(s) for 25 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-Western: 1 Protein-RNA: 1
Genetic Interactions	Phenotypic Enhancement: 14 Phenotypic Suppression: 8

Sequence Information

ChrIV:1362174 to 1361113 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1062	1362174..1361113	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002859

YHP1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for YHP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for YHP1]

1)	Pramila T, et al. (2002) Conserved homeodomain proteins interact with MADS box protein Mcm1 to restrict ECB-dependent transcription to the M/G1 phase of the cell cycle. Genes Dev 16(23):3034-45
2)	Breeden LL (2003) Periodic transcription: a cycle within a cycle. Curr Biol 13(1):R31-8
3)	Kunoh T, et al. (2000) YHP1 encodes a new homeoprotein that binds to the IME1 promoter in Saccharomyces cerevisiae. Yeast 16(5):439-49

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