IMA1/YGR287C Summary Help

Standard Name IMA1 1, 2
Systematic Name YGR287C
Feature Type ORF, Verified
Description Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; member of the IMA isomaltase family (1, 2, 3, 4, 5, 6, 7, 8)
Name Description IsoMAltase 1, 2
Chromosomal Location
ChrVII:1068991 to 1067222 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All IMA1 GO evidence and references
  View Computational GO annotations for IMA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
36 total interaction(s) for 36 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Protein-peptide: 5
  • Reconstituted Complex: 6

Genetic Interactions
  • Negative Genetic: 18
  • Phenotypic Enhancement: 1
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 589
Molecular Weight (Da) 68,591
Isoelectric Point (pI) 5.22
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:1068991 to 1067222 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1770 1068991..1067222 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003519
References cited on this page View Complete Literature Guide for IMA1
1) Teste MA, et al.  (2010) Characterization of a New Multigene Family Encoding Isomaltases in the Yeast Saccharomyces cerevisiae, the IMA Family. J Biol Chem 285(35):26815-24
2) Naumoff DG and Naumov GI  (2010) Discovery of a novel family of alpha-glucosidase IMA genes in yeast Saccharomyces cerevisiae. Dokl Biochem Biophys 432():114-6
3) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
4) Fleischer TC, et al.  (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307
5) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
6) Yamamoto K, et al.  (2004) Val216 decides the substrate specificity of alpha-glucosidase in Saccharomyces cerevisiae. Eur J Biochem 271(16):3414-20
7) Brown CA, et al.  (2010) Rapid expansion and functional divergence of subtelomeric gene families in yeasts. Curr Biol 20(10):895-903
8) Deng X, et al.  (2014) Similarities and differences in the biochemical and enzymological properties of the four isomaltases from Saccharomyces cerevisiae. FEBS Open Bio 4():200-12