SDA1/YGR245C Summary Help

Standard Name SDA1 1
Systematic Name YGR245C
Feature Type ORF, Verified
Description Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; involved in 60S ribosome biogenesis (1, 2, 3)
Name Description Severe Depolymerization of Actin 1
Chromosomal Location
ChrVII:982068 to 979765 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SDA1 GO evidence and references
  View Computational GO annotations for SDA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
conditional
null
overexpression
repressible
Large-scale survey
null
reduction of function
repressible
Resources
190 total interaction(s) for 93 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 120
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 9
  • Co-purification: 19
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 36
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 767
Molecular Weight (Da) 86,618
Isoelectric Point (pI) 6.92
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:982068 to 979765 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2304 982068..979765 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003477
References cited on this page View Complete Literature Guide for SDA1
1) Buscemi G, et al.  (2000) The Saccharomyces cerevisiae SDA1 gene is required for actin cytoskeleton organization and cell cycle progression. J Cell Sci 113 ( Pt 7)():1199-211
2) Zimmerman ZA and Kellogg DR  (2001) The Sda1 protein is required for passage through start. Mol Biol Cell 12(1):201-19
3) Babbio F, et al.  (2004) Expression and localization studies of hSDA, the human ortholog of the yeast SDA1 gene. Cell Cycle 3(4):486-90