KEL2/YGR238C Summary

KEL2 BASIC INFORMATION

Standard Name	KEL2 1
Systematic Name	YGR238C
Feature Type	ORF, Verified
Description	Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate (1, 2)
Name Description	KELch repeat 1

GO Annotations	All KEL2 GO evidence and references
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	conjugation with cellular fusion (IGI) negative regulation of exit from mitosis (IMP, IPI)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) mating projection tip (IDA)
High-throughput	mating projection tip (IDA)

Mutant Phenotype	All KEL2 Phenotype details and references
Large-scale survey
null	filamentous growth: decreased invasive growth: absent sporulation: normal viable
overexpression	resistance to rapamycin: decreased

Interactions	KEL2 All interactions details and references
	22 total interaction(s) for 15 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 3 PCA: 2 Two-hybrid: 5
Genetic Interactions	Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Synthetic Growth Defect: 2 Synthetic Rescue: 1

Sequence Information

ChrVII:968692 to 966044 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-29 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2649	968692..966044	2005-11-29	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003470

KEL2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for KEL2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KEL2]

1)	Philips J and Herskowitz I (1998) Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae. J Cell Biol 143(2):375-89
2)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64

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