YHB1/YGR234W Summary Help

Standard Name YHB1
Systematic Name YGR234W
Alias YHB4
Feature Type ORF, Verified
Description Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress (1, 2, 3, 4)
Name Description Yeast HemogloBin-like protein
Chromosomal Location
ChrVII:959904 to 961103 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YHB1 GO evidence and references
  View Computational GO annotations for YHB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 26 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
69 total interaction(s) for 59 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 48
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • PCA: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 3
  • Phenotypic Enhancement: 4
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 399
Molecular Weight (Da) 44,646
Isoelectric Point (pI) 6.25
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:959904 to 961103 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1200 959904..961103 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003466
References cited on this page View Complete Literature Guide for YHB1
1) Zhu H and Riggs AF  (1992) Yeast flavohemoglobin is an ancient protein related to globins and a reductase family. Proc Natl Acad Sci U S A 89(11):5015-9
2) Liu L, et al.  (2000) Protection from nitrosative stress by yeast flavohemoglobin. Proc Natl Acad Sci U S A 97(9):4672-6
3) Cassanova N, et al.  (2005) Yeast flavohemoglobin, a nitric oxide oxidoreductase, is located in both the cytosol and the mitochondrial matrix: effects of respiration, anoxia, and the mitochondrial genome on its intracellular level and distribution. J Biol Chem 280(9):7645-53
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76