Standard Name	AMA1 1
Systematic Name	YGR225W
Alias	SPO70 2
Feature Type	ORF, Verified
Description	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis (1, 3)
Name Description	Activator of Meiotic APC/C 1

Chromosomal Location	ChrVII:945145 to 947019 | ORF Map | GBrowse

	View Computational GO annotations for AMA1
Molecular Function
Manually curated	enzyme activator activity (IMP, IPI)
Biological Process
Manually curated	ascospore formation (IMP) ascospore wall assembly (IMP) meiosis I (IMP) positive regulation of protein catabolic process (IMP, IPI)
Cellular Component
Manually curated	anaphase-promoting complex (IPI)

Classical genetics
null	glucosamine accumulation: absent meiosis: decreased Clb1p accumulation: increased Ssp1 accumulation: increased Smk1-HA modification: decreased spore wall formation: abnormal sporulation: decreased
overexpression	Clb1p accumulation: decreased
reduction of function	sporulation: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to cycloheximide: decreased resistance to streptomycin: decreased spore wall formation: absent sporulation: abnormal sporulation: absent sporulation efficiency: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	20 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-Western: 3 Biochemical Activity: 1 Two-hybrid: 2
Genetic Interactions	Dosage Lethality: 2 Negative Genetic: 4 Phenotypic Suppression: 6 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:945145 to 947019 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2005-11-29
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1183 945145..946327 2011-02-03 2000-12-01 Intron 1184..1276 946328..946420 2011-02-03 2000-12-01 CDS 1277..1875 946421..947019 2011-02-03 2005-11-29
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (1184 - 1276)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003457