TOS2/YGR221C Summary

TOS2 BASIC INFORMATION

Standard Name	TOS2
Systematic Name	YGR221C
Feature Type	ORF, Verified
Description	Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p (1, 2)
Name Description	Target Of Sbf

GO Annotations	All TOS2 GO evidence and references
	View Computational GO annotations for TOS2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	budding cell bud growth (IMP, IPI)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA)

Mutant Phenotype	All TOS2 Phenotype details and references
Classical genetics
null	thermotolerance: decreased viable
overexpression	cell shape: abnormal
Large-scale survey
null	resistance to GDP-beta-S: decreased viable

Interactions	TOS2 All interactions details and references
	16 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Biochemical Activity: 2 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 5 Phenotypic Suppression: 3

Sequence Information

ChrVII:938995 to 937127 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1869	938995..937127	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003453

TOS2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for TOS2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TOS2]

1)	Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71
2)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64

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