Standard Name	CRM1 1
Systematic Name	YGR218W
Alias	KAP124 , XPO1
Feature Type	ORF, Verified
Description	Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin (2, 3)
Name Description	Chromosome Region Maintenance 1

Chromosomal Location	ChrVII:932541 to 935795 | ORF Map | GBrowse

	View Computational GO annotations for CRM1
Molecular Function
Manually curated	protein transporter activity (IDA, IMP)
Biological Process
Manually curated	mRNA export from nucleus (IMP) protein export from nucleus (IMP) protein localization to kinetochore (IGI) ribosomal large subunit export from nucleus (IMP)
Cellular Component
Manually curated	kinetochore (IDA) nucleus (IDA) spindle pole body (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
conditional	actin cytoskeleton morphology: abnormal endocytosis: decreased nuclear export: decreased Mad1p-GFP distribution: abnormal Dna2 distribution: abnormal GFP-Scd5p distribution: abnormal
unspecified	Spc72p distribution: abnormal
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal
null	haploproficient inviable
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	200 total interaction(s) for 128 unique genes/features.
Physical Interactions	Affinity Capture-MS: 47 Affinity Capture-RNA: 2 Affinity Capture-Western: 17 Biochemical Activity: 1 Co-localization: 4 Co-purification: 1 Protein-peptide: 1 Reconstituted Complex: 13 Two-hybrid: 70
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 6 Negative Genetic: 18 Phenotypic Enhancement: 5 Phenotypic Suppression: 1 Positive Genetic: 3 Synthetic Growth Defect: 3 Synthetic Lethality: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:932541 to 935795 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3255 932541..935795 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003450