CRM1/YGR218W Summary Help

Standard Name CRM1 1
Systematic Name YGR218W
Alias KAP124 , XPO1
Feature Type ORF, Verified
Description Major karyopherin; involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin (2, 3)
Name Description Chromosome Region Maintenance 1
Chromosomal Location
ChrVII:932541 to 935795 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CRM1 GO evidence and references
  View Computational GO annotations for CRM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
conditional
overexpression
unspecified
Large-scale survey
conditional
null
overexpression
Resources
206 total interaction(s) for 131 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 51
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 17
  • Biochemical Activity: 1
  • Co-localization: 4
  • Co-purification: 2
  • Protein-peptide: 1
  • Reconstituted Complex: 13
  • Two-hybrid: 70

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 6
  • Negative Genetic: 18
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 1
  • Positive Genetic: 3
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,084
Molecular Weight (Da) 124,103
Isoelectric Point (pI) 5.24
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:932541 to 935795 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3255 932541..935795 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003450
References cited on this page View Complete Literature Guide for CRM1
1) Toda T, et al.  (1992) Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1. Mol Cell Biol 12(12):5474-84
2) Maurer P, et al.  (2001) The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p). Mol Biol Cell 12(3):539-49
3) Johnson AW, et al.  (2002) Nuclear export of ribosomal subunits. Trends Biochem Sci 27(11):580-5