GPI1/YGR216C Summary Help

Standard Name GPI1 1
Systematic Name YGR216C
Feature Type ORF, Verified
Description Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs (1, 2, 3, 4)
Name Description GlycosylPhosphatidylInositol anchoring biosynthesis 1, 3
Chromosomal Location
ChrVII:924462 to 922633 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All GPI1 GO evidence and references
  View Computational GO annotations for GPI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
repressible
Resources
77 total interaction(s) for 74 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Co-purification: 1
  • PCA: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 61
  • Phenotypic Suppression: 1
  • Positive Genetic: 4
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 609
Molecular Weight (Da) 70,354
Isoelectric Point (pI) 9.85
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:924462 to 922633 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1830 924462..922633 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003448
References cited on this page View Complete Literature Guide for GPI1
1) Leidich SD, et al.  (1994) A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis. J Biol Chem 269(14):10193-6
2) Tiede A, et al.  (1998) Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants. Biochem J 334 ( Pt 3)():609-16
3) Leidich SD and Orlean P  (1996) Gpi1, a Saccharomyces cerevisiae protein that participates in the first step in glycosylphosphatidylinositol anchor synthesis. J Biol Chem 271(44):27829-37
4) Watanabe R, et al.  (1998) The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. EMBO J 17(4):877-85