ADE3/YGR204W Summary Help

Standard Name ADE3
Systematic Name YGR204W
Feature Type ORF, Verified
Description Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase; involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine (1, 2, 3)
Name Description ADEnine requiring
Chromosomal Location
ChrVII:905934 to 908774 | ORF Map | GBrowse
Gbrowse
Genetic position: 159 cM
Gene Ontology Annotations All ADE3 GO evidence and references
  View Computational GO annotations for ADE3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 24 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
Resources
43 total interaction(s) for 36 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-RNA: 3
  • Co-purification: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 1
  • Phenotypic Enhancement: 4
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 7
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 946
Molecular Weight (Da) 102,204
Isoelectric Point (pI) 6.83
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:905934 to 908774 | ORF Map | GBrowse
SGD ORF map
Genetic position: 159 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2841 905934..908774 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003436
References cited on this page View Complete Literature Guide for ADE3
1) Song JM and Rabinowitz JC  (1993) Function of yeast cytoplasmic C1-tetrahydrofolate synthase. Proc Natl Acad Sci U S A 90(7):2636-40
2) McKenzie KQ and Jones EW  (1977) Mutants of formyltetrahydrofolate interconversion pathway of Saccharomyces cerevisiae. Genetics 86(1):85-102
3) Jones EW and Fink GR  (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press