Standard Name	ESP1
Systematic Name	YGR098C
Feature Type	ORF, Verified
Description	Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress (1, 2, 3, 4)
Name Description	Extra Spindle Pole bodies

Chromosomal Location	ChrVII:687458 to 682566 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 60 cM

	View Computational GO annotations for ESP1
Molecular Function
Manually curated	cysteine-type endopeptidase activity (IDA)
Biological Process
Manually curated	apoptotic process (IMP) mitotic sister chromatid segregation (IMP, IPI) negative regulation of protein phosphatase type 2A activity (IMP, IPI) regulation of exit from mitosis (IGI, IPI) regulation of mitotic spindle elongation (IGI, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA) spindle (IDA)
High-throughput	cytoplasm (IDA) mitochondrion (IDA) nucleus (IDA)

Classical genetics
overexpression	apoptosis: increased Mcd1-GFP distribution: abnormal
repressible	Mcd1-GFP distribution: abnormal
Large-scale survey
null	inviable
reduction of function	competitive fitness: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	49 total interaction(s) for 34 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 2 Affinity Capture-Western: 10 Biochemical Activity: 1 Two-hybrid: 3
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Dosage Rescue: 4 Phenotypic Enhancement: 4 Phenotypic Suppression: 10 Synthetic Growth Defect: 2 Synthetic Lethality: 4 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:687458 to 682566 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 60 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4893 687458..682566 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003330