ASK10/YGR097W Summary Help

Standard Name ASK10 1
Systematic Name YGR097W
Alias RGC2 2
Feature Type ORF, Verified
Description Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication (2, 3, 4)
Name Description Activator of SKn7 1
Chromosomal Location
ChrVII:678695 to 682135 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ASK10 GO evidence and references
  View Computational GO annotations for ASK10
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
211 total interaction(s) for 193 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 29
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 5
  • Biochemical Activity: 1
  • Protein-RNA: 1
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 52
  • Phenotypic Enhancement: 2
  • Positive Genetic: 106
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,146
Molecular Weight (Da) 126,863
Isoelectric Point (pI) 10.11
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:678695 to 682135 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3441 678695..682135 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003329
References cited on this page View Complete Literature Guide for ASK10
1) Page N, et al.  (1996) Identification of ASK10 as a multicopy activator of Skn7p-dependent transcription of a HIS3 reporter gene. Yeast 12(3):267-72
2) Beese SE, et al.  (2009) Identification of positive regulators of the yeast fps1 glycerol channel. PLoS Genet 5(11):e1000738
3) Cohen TJ, et al.  (2003) Ask10p mediates the oxidative stress-induced destruction of the Saccharomyces cerevisiae C-type cyclin Ume3p/Srb11p. Eukaryot Cell 2(5):962-70
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61