SPR3/YGR059W Summary Help

Standard Name SPR3 1
Systematic Name YGR059W
Feature Type ORF, Verified
Description Sporulation-specific homolog of the CDC3/10/11/12 family of genes; septin protein involved in sporulation; regulated by ABFI; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes (2 and see Summary Paragraph)
Name Description SPorulation Regulated 1
Chromosomal Location
ChrVII:607563 to 609101 | ORF Map | GBrowse
Gene Ontology Annotations All SPR3 GO evidence and references
  View Computational GO annotations for SPR3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Large-scale survey
105 total interaction(s) for 92 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 1
  • Two-hybrid: 54

Genetic Interactions
  • Negative Genetic: 44
  • Positive Genetic: 4
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1

Expression Summary
Length (a.a.) 512
Molecular Weight (Da) 59,845
Isoelectric Point (pI) 7.34
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:607563 to 609101 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1539 607563..609101 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003291

SPR3 encodes a septin (3). Septins are a family of conserved proteins first identified in yeast and subsequently found in numerous other fungi and animals, including human, mouse, Drosophila, and C. elegans (reviewed in 4 and 5). Four yeast septins, Cdc3p Cdc10p, Cdc11p, and Cdc12p, have been studied extensively; they are required for cytokinesis, axial bud site selection, and the correct localization of several other proteins involved in cytokinesis, morphogenesis, and bud site selection (5, 6).

SPR3 is expressed specifically during meiotic divisions and ascospore formation (7). Deletion of SPR3 causes no apparent defect in mitotically growing cells, but causes a sporulation defect in some strains (3). The septins Spr3p and Spr28p localize to the prospore wall along with Cdc3p and Cdc11p (3, 8).

Last updated: 1999-12-09 Contact SGD

References cited on this page View Complete Literature Guide for SPR3
1) Holaway BL, et al.  (1987) Transcriptional regulation of sporulation genes in yeast. Mol Gen Genet 210(3):449-59
2) Ozsarac N, et al.  (1995) The SPR3 gene encodes a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilaments and is regulated by ABFI. Gene 164(1):157-62
3) Fares H, et al.  (1996) Identification of a developmentally regulated septin and involvement of the septins in spore formation in Saccharomyces cerevisiae. J Cell Biol 132(3):399-411
4) Longtine MS, et al.  (1996) The septins: roles in cytokinesis and other processes. Curr Opin Cell Biol 8(1):106-19
5) Field CM and Kellogg D  (1999) Septins: cytoskeletal polymers or signalling GTPases? Trends Cell Biol 9(10):387-94
6) Madden K and Snyder M  (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744
7) Ozsarac N, et al.  (1997) Regulation of gene expression during meiosis in Saccharomyces cerevisiae: SPR3 is controlled by both ABFI and a new sporulation control element. Mol Cell Biol 17(3):1152-9
8) De Virgilio C, et al.  (1996) SPR28, a sixth member of the septin gene family in Saccharomyces cerevisiae that is expressed specifically in sporulating cells. Microbiology 142 ( Pt 10):2897-905