Systematic Name	YGR054W
Feature Type	ORF, Verified
Description	Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A (1, 2)

Chromosomal Location	ChrVII:596693 to 598621 | ORF Map | GBrowse

	View Computational GO annotations for YGR054W
Molecular Function
Manually curated	translation initiation factor activity (IDA, IMP)
Biological Process
Manually curated	translational initiation (IDA, IMP)
Cellular Component
Manually curated	cytosolic ribosome (IDA) cytosolic small ribosomal subunit (IDA)
High-throughput	colocalizes_with ribosome (IDA)

Classical genetics
null	resistance to tellurite: decreased
Large-scale survey
null	competitive fitness: decreased haploproficient resistance to propolis extract: decreased resistance to nickel sulfate: decreased resistance to tunicamycin: increased resistance to bleomycin: increased resistance to PM02734: increased resistance to cycloheximide: decreased resistance to caffeine: decreased resistance to sodium selenide: decreased starvation resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	98 total interaction(s) for 75 unique genes/features.
Physical Interactions	Affinity Capture-MS: 40 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Biochemical Activity: 1 PCA: 13 Reconstituted Complex: 4
Genetic Interactions	Negative Genetic: 14 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 13 Synthetic Growth Defect: 5 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:596693 to 598621 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1929 596693..598621 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003286