Standard Name	UFD1 1
Systematic Name	YGR048W
Feature Type	ORF, Verified
Description	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP) (2, 3, 4, 5, 6, 7, 8)
Name Description	Ubiquitin Fusion Degradation protein 1

Chromosomal Location	ChrVII:589826 to 590911 | ORF Map | GBrowse

	View Computational GO annotations for UFD1
Molecular Function
Manually curated	polyubiquitin binding (IDA) ubiquitin binding (IDA)
Biological Process
Manually curated	cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process (IMP) ER-associated misfolded protein catabolic process (IMP) ER-associated protein catabolic process (IMP) positive regulation of protein localization to nucleus (IMP) proteasomal ubiquitin-dependent protein catabolic process (IMP) retrograde protein transport, ER to cytosol (IMP) ribosome-associated ubiquitin-dependent protein catabolic process (IMP)
Cellular Component
Manually curated	Cdc48p-Npl4p-Ufd1p AAA ATPase complex (IDA) nucleus (IDA) RQC complex (IDA)

Classical genetics
conditional	cell cycle progression in G1 phase: delayed CPY* accumulation: increased Ub-P-Bgal accumulation: increased Ubiquitin conjugates accumulation: increased Fbp1p accumulation: increased Cdc48p distribution: abnormal Npl4p-myc distribution: abnormal CPY* distribution: abnormal myc-Spt23p distribution: abnormal GFP-Spt23p distribution: abnormal GFP-Mga2p modification: decreased resistance to hygromycin B: decreased resistance to paromomycin: decreased toxin resistance: decreased
null	inviable
overexpression	toxin resistance: increased
unspecified	Ura3p-CL1 accumulation: increased
Large-scale survey
conditional	resistance to benomyl: decreased
null	haploproficient inviable
reduction of function	competitive fitness: normal
repressible	chromosome/plasmid maintenance: decreased mitochondrial morphology: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	130 total interaction(s) for 77 unique genes/features.
Physical Interactions	Affinity Capture-MS: 31 Affinity Capture-Western: 33 Co-purification: 2 PCA: 2 Reconstituted Complex: 1 Two-hybrid: 16
Genetic Interactions	Negative Genetic: 36 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Positive Genetic: 1 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:589826 to 590911 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1086 589826..590911 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003280