ACB1/YGR037C Summary Help

Standard Name ACB1 1, 2, 3
Systematic Name YGR037C
Feature Type ORF, Verified
Description Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress (4, 5, 6, 7)
Name Description Acyl-CoA-Binding 1, 5
Chromosomal Location
ChrVII:559994 to 559731 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All ACB1 GO evidence and references
  View Computational GO annotations for ACB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 9 genes
Classical genetics
Large-scale survey
68 total interaction(s) for 65 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 4
  • PCA: 9
  • Protein-peptide: 1
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 14
  • Positive Genetic: 16
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1

Expression Summary
Length (a.a.) 87
Molecular Weight (Da) 10,061
Isoelectric Point (pI) 4.67
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:559994 to 559731 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..264 559994..559731 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003269
References cited on this page View Complete Literature Guide for ACB1
1) Borsting C, et al.  (1997) Saccharomyces carlsbergensis contains two functional genes encoding the acyl-CoA binding protein, one similar to the ACB1 gene from S. cerevisiae and one identical to the ACB1 gene from S. monacensis. Yeast 13(15):1409-21
2) Mueller, L., et al.  (1996) RanBP3 is a nuclear Ran-GTP binding protein that forms a Ran-dependent complex with RCC1 in vivo and in vitro. Unpublished
3) Rose, T.M.  (1994) Personal Communication, Mortimer Map Edition 12
4) Schjerling CK, et al.  (1996) Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae. J Biol Chem 271(37):22514-21
5) Rose TM, et al.  (1992) Molecular cloning of the gene for the yeast homolog (ACB) of diazepam binding inhibitor/endozepine/acyl-CoA-binding protein. Proc Natl Acad Sci U S A 89(23):11287-91
6) Duran JM, et al.  (2010) Unconventional secretion of Acb1 is mediated by autophagosomes. J Cell Biol 188(4):527-36
7) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76