ERV1/YGR029W Summary Help

Standard Name ERV1 1
Systematic Name YGR029W
Feature Type ORF, Verified
Description Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria, and in the intermembrane space oxidizes Mia40p as part of a disulfide relay system that promotes intermembrane space retention of imported proteins; functional ortholog of human GFER (ALR) (2, 3, 4, 5)
Name Description Essential for Respiration and Viability 1
Chromosomal Location
ChrVII:543553 to 544205 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ERV1 GO evidence and references
  View Computational GO annotations for ERV1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
conditional
reduction of function
repressible
Large-scale survey
conditional
null
Resources
45 total interaction(s) for 23 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 6
  • Affinity Capture-Western: 9
  • Biochemical Activity: 8
  • Co-purification: 2
  • Reconstituted Complex: 8
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 8
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 189
Molecular Weight (Da) 21,639
Isoelectric Point (pI) 8.21
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:543553 to 544205 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2000-07-14
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..86 543553..543638 2011-02-03 2000-07-14
Intron 87..169 543639..543721 2011-02-03 2000-07-14
CDS 170..653 543722..544205 2011-02-03 2000-07-14
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003261
References cited on this page View Complete Literature Guide for ERV1
1) Lisowsky T  (1992) Dual function of a new nuclear gene for oxidative phosphorylation and vegetative growth in yeast. Mol Gen Genet 232(1):58-64
2) Lee J, et al.  (2000) Erv1p from Saccharomyces cerevisiae is a FAD-linked sulfhydryl oxidase. FEBS Lett 477(1-2):62-6
3) Lange H, et al.  (2001) An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins. EMBO Rep 2(8):715-20
4) Mesecke N, et al.  (2005) A disulfide relay system in the intermembrane space of mitochondria that mediates protein import. Cell 121(7):1059-69
5) Banci L, et al.  (2013) An intrinsically disordered domain has a dual function coupled to compartment-dependent redox control. J Mol Biol 425(3):594-608