HFM1/YGL251C Summary Help

Standard Name HFM1
Systematic Name YGL251C
Alias MER3 1
Feature Type ORF, Verified
Description Meiosis specific DNA helicase; involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity (2, 3, 4, 5)
Name Description Helicase Family Member
Chromosomal Location
ChrVII:31636 to 27921 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HFM1 GO evidence and references
  View Computational GO annotations for HFM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
unspecified
Resources
14 total interaction(s) for 14 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • PCA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 3
  • Phenotypic Suppression: 1
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,187
Molecular Weight (Da) 135,071
Isoelectric Point (pI) 7.59
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:31636 to 27921 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2000-07-14 | Sequence: 2000-07-14
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..58 31636..31579 2000-07-14 2000-07-14
Intron 59..210 31578..31427 2000-07-14 2000-07-14
CDS 211..3716 31426..27921 2000-07-14 2000-07-14
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003220
References cited on this page View Complete Literature Guide for HFM1
1) Nakagawa T and Ogawa H  (1999) The Saccharomyces cerevisiae MER3 gene, encoding a novel helicase-like protein, is required for crossover control in meiosis. EMBO J 18(20):5714-23
2) Coissac E, et al.  (1996) Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae. Yeast 12(15):1555-62
3) Nakagawa T, et al.  (2001) The MER3 helicase involved in meiotic crossing over is stimulated by single-stranded DNA-binding proteins and unwinds DNA in the 3' to 5' direction. J Biol Chem 276(34):31487-93
4) Nakagawa T and Kolodner RD  (2002) Saccharomyces cerevisiae Mer3 is a DNA helicase involved in meiotic crossing over. Mol Cell Biol 22(10):3281-91
5) Nakagawa T and Kolodner RD  (2002) The MER3 DNA helicase catalyzes the unwinding of holliday junctions. J Biol Chem 277(31):28019-24