BRR6/YGL247W Summary Help

Standard Name BRR6 1
Systematic Name YGL247W
Feature Type ORF, Verified
Description Essential nuclear envelope integral membrane protein; required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism (1, 2)
Name Description Bad Response to Refrigeration 3
Chromosomal Location
ChrVII:36933 to 37526 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All BRR6 GO evidence and references
  View Computational GO annotations for BRR6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
conditional
Large-scale survey
conditional
null
overexpression
Resources
27 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • PCA: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 4
  • Synthetic Lethality: 16

Resources
Expression Summary
histogram
Resources
Length (a.a.) 197
Molecular Weight (Da) 22,807
Isoelectric Point (pI) 8.19
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:36933 to 37526 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..594 36933..37526 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003216
References cited on this page View Complete Literature Guide for BRR6
1) de Bruyn Kops A and Guthrie C  (2001) An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport. EMBO J 20(15):4183-93
2) Hodg CA, et al.  (2010) Integral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmic reticulum. J Cell Sci 123(Pt 1):141-151
3) Noble SM and Guthrie C  (1996) Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics 143(1):67-80