Standard Name	BRR6
Systematic Name	YGL247W
Feature Type	ORF, Verified
Description	Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism (1, 2)
Name Description	Bad Response to Refrigeration 1, 3

Chromosomal Location	ChrVII:36933 to 37526 | ORF Map | GBrowse

	View Computational GO annotations for BRR6
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular lipid metabolic process (IGI) mRNA export from nucleus (IMP) protein export from nucleus (IMP)
Cellular Component
Manually curated	nuclear envelope (IDA)

Classical genetics
conditional	triglyceride accumulation: increased cold sensitivity: increased lipid particle morphology: abnormal nuclear morphology: abnormal Nup82p-GFP distribution: abnormal resistance to oleic acid: decreased resistance to cerulenin: decreased resistance to terbinafine: decreased resistance to cis-ketoconazole: decreased
Large-scale survey
null	inviable starvation resistance: decreased
overexpression	vegetative growth: decreased rate
unspecified	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	27 total interaction(s) for 22 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 PCA: 1 Two-hybrid: 3
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 4 Synthetic Lethality: 16
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:36933 to 37526 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..594 36933..37526 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003216