KAP114/YGL241W Summary

KAP114 BASIC INFORMATION

Standard Name	KAP114 1
Systematic Name	YGL241W
Feature Type	ORF, Verified
Description	Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear (2, 3)
Name Description	KAryoPherin 1

GO Annotations	All KAP114 GO evidence and references
	View Computational GO annotations for KAP114
Molecular Function
Manually curated	protein transporter activity (IMP, IPI, ISS)
Biological Process
Manually curated	protein import into nucleus (IMP, ISS)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Mutant Phenotype	All KAP114 Phenotype details and references
Classical genetics
null	nuclear import: decreased
Large-scale survey
null	viable

Interactions	KAP114 All interactions details and references
	71 total interaction(s) for 24 unique genes/features.
Physical Interactions	Affinity Capture-MS: 25 Affinity Capture-RNA: 1 Affinity Capture-Western: 14 Protein-peptide: 2 Reconstituted Complex: 19 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 5 Phenotypic Suppression: 2 Synthetic Growth Defect: 1

Sequence Information

ChrVII:45445 to 48459 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3015	45445..48459	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003210

KAP114 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for KAP114

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KAP114]

1)	Pemberton LF, et al. (1999) Nuclear import of the TATA-binding protein: mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting. J Cell Biol 145(7):1407-17
2)	Morehouse H, et al. (1999) The importin/karyopherin Kap114 mediates the nuclear import of TATA-binding protein. Proc Natl Acad Sci U S A 96(22):12542-7
3)	Mosammaparast N, et al. (2002) A role for nucleosome assembly protein 1 in the nuclear transport of histones H2A and H2B. EMBO J 21(23):6527-38

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