Standard Name	HAP2 (see Nomenclature conflict Note)
Systematic Name	YGL237C
Feature Type	ORF, Verified
Description	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding (1, 2, 3, 4, 5)
Name Description	Heme Activator Protein 4, 6

Chromosomal Location	ChrVII:53528 to 52731 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -148 cM

	View Computational GO annotations for HAP2
Molecular Function
Manually curated	contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA)
Biological Process
Manually curated	carbon catabolite activation of transcription from RNA polymerase II promoter (IDA) regulation of cellular respiration (IMP)
Cellular Component
Manually curated	CCAAT-binding factor complex (IDA, IPI)
High-throughput	nucleus (IDA)

Binding motifs	Predicted HAP2 Binding Site Locations
	CCAAT 7 [Search intergenic regions for CCAAT]
Resources	ScerTF | YeTFaSCo

Classical genetics
null	glycogen accumulation: abnormal dessication resistance: decreased GDH3 accumulation: decreased resistance to quinine: decreased resistance to sirolimus: increased resistance to fenpropimorph: increased
reduction of function	mitochondrial rho- mutation frequency: increased cytochromes accumulation: decreased utilization of carbon source: decreased
Large-scale survey
null	UV resistance: decreased cell size: decreased glutathione excretion: increased chitin deposition: normal competitive fitness: decreased dessication resistance: decreased resistance to streptomycin: decreased resistance to sirolimus: increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to ethanol: decreased resistance to wortmannin: normal resistance to methyl methanesulfonate: decreased resistance to cycloheximide: decreased respiratory growth: absent respiratory growth: decreased rate sporulation efficiency: decreased utilization of carbon source: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	175 total interaction(s) for 132 unique genes/features.
Physical Interactions	Affinity Capture-MS: 39 Affinity Capture-RNA: 2 Reconstituted Complex: 8 Two-hybrid: 9
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 94 Phenotypic Enhancement: 1 Positive Genetic: 9 Synthetic Growth Defect: 8 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:53528 to 52731 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -148 cM
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..798 53528..52731 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003206