Standard Name	ADE5,7
Systematic Name	YGL234W
Feature Type	ORF, Verified
Description	Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities (1)
Name Description	ADEnine requiring

Chromosomal Location	ChrVII:56482 to 58890 | ORF Map | GBrowse
	Genetic position: -152 cM

	View Computational GO annotations for ADE5,7
Molecular Function
Manually curated	phosphoribosylamine-glycine ligase activity (TAS) phosphoribosylformylglycinamidine cyclo-ligase activity (TAS)
Biological Process
Manually curated	'de novo' IMP biosynthetic process (TAS) purine nucleobase metabolic process (TAS) purine nucleotide biosynthetic process (TAS)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	de novo biosynthesis of purine nucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Classical genetics
null	auxotrophy resistance to tellurite: decreased
Large-scale survey
null	competitive fitness: decreased metal resistance: increased utilization of nitrogen source: absent viable
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	37 total interaction(s) for 32 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-RNA: 2 Biochemical Activity: 2 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 8 Phenotypic Suppression: 1 Positive Genetic: 3 Synthetic Growth Defect: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:56482 to 58890 | ORF Map | GBrowse
	Genetic position: -152 cM
Last Update	Coordinates: 2004-07-15 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2409 56482..58890 2004-07-15 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003203