NCS6/YGL211W Summary Help

Standard Name NCS6 1
Systematic Name YGL211W
Alias YGL210W-A , TUC1 2
Feature Type ORF, Verified
Description Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae (2, 3, 4)
Name Description Needs Cla4 to Survive 1
Chromosomal Location
ChrVII:92512 to 93591 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NCS6 GO evidence and references
  View Computational GO annotations for NCS6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
169 total interaction(s) for 122 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 3
  • Protein-peptide: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 112
  • Positive Genetic: 11
  • Synthetic Growth Defect: 24
  • Synthetic Lethality: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 359
Molecular Weight (Da) 39,987
Isoelectric Point (pI) 8.97
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:92512 to 93591 | ORF Map | GBrowse
This feature contains embedded feature(s): YGL210W-A
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2004-07-20
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1080 92512..93591 2011-02-03 2004-07-20
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003179
References cited on this page View Complete Literature Guide for NCS6
1) Goehring AS, et al.  (2003) Synthetic lethal analysis implicates Ste20p, a p21-activated potein kinase, in polarisome activation. Mol Biol Cell 14(4):1501-16
2) Bjork GR, et al.  (2007) A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast. RNA 13(8):1245-55
3) Goehring AS, et al.  (2003) Urmylation: a ubiquitin-like pathway that functions during invasive growth and budding in yeast. Mol Biol Cell 14(11):4329-41
4) Kushner DB, et al.  (2003) Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus. Proc Natl Acad Sci U S A 100(26):15764-9