Standard Name	MIG2 1
Systematic Name	YGL209W
Alias	MLZ1 2
Feature Type	ORF, Verified
Description	Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description	Multicopy Inhibitor of GAL gene expression

Chromosomal Location	ChrVII:95858 to 97006 | ORF Map | GBrowse

	View Computational GO annotations for MIG2
Molecular Function
Manually curated	RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription (IDA, IGI)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter by glucose (IDA, IGI, IMP) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation (IGI) positive regulation of transcription from RNA polymerase II promoter (IGI, IMP)
Cellular Component
Manually curated	mitochondrion (IDA) nucleus (IDA)
High-throughput	nucleus (IDA)

Binding motifs	CCCCRC 6 [Search intergenic regions for CCCCRC] TACCCCGCANT 7 [Search intergenic regions for TACCCCGCANT]
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
null	mitochondrial morphology: abnormal resistance to quinine: decreased viable
Large-scale survey
null	competitive fitness: increased haploinsufficient resistance to propolis extract: decreased resistance to neomycin: decreased resistance to cycloheximide: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	42 total interaction(s) for 30 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Biochemical Activity: 4 PCA: 1 Protein-RNA: 2 Reconstituted Complex: 2 Two-hybrid: 4
Genetic Interactions	Negative Genetic: 10 Phenotypic Enhancement: 5 Phenotypic Suppression: 4 Synthetic Growth Defect: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:95858 to 97006 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1149 95858..97006 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003177