Standard Name	KEX1
Systematic Name	YGL203C
Feature Type	ORF, Verified
Description	Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins (1, 2, 3)
Name Description	Killer EXpression defective

Chromosomal Location	ChrVII:114664 to 112475 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -131 cM

	View Computational GO annotations for KEX1
Molecular Function
Manually curated	serine-type carboxypeptidase activity (TAS)
Biological Process
Manually curated	apoptotic process (IMP)
Cellular Component
Manually curated	trans-Golgi network (IDA)

Classical genetics
null	resistance to hypochlorous acid: increased toxin resistance: increased
Large-scale survey
null	auxotrophy inositol excretion: increased competitive fitness: increased haploproficient resistance to arsenite(3-): decreased resistance to hydrogen chloride: decreased resistance to benzo[a]pyrene: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	132 total interaction(s) for 96 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 PCA: 49 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Negative Genetic: 59 Phenotypic Suppression: 1 Positive Genetic: 9 Synthetic Growth Defect: 3 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:114664 to 112475 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -131 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2190 114664..112475 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003171