KEX1/YGL203C Summary Help

Standard Name KEX1 1
Systematic Name YGL203C
Feature Type ORF, Verified
Description Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins (2, 3, 4)
Name Description Killer EXpression defective 1
Chromosomal Location
ChrVII:114664 to 112475 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -131 cM
Gene Ontology Annotations All KEX1 GO evidence and references
  View Computational GO annotations for KEX1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
144 total interaction(s) for 102 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • PCA: 49
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Negative Genetic: 67
  • Phenotypic Suppression: 1
  • Positive Genetic: 12
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 729
Molecular Weight (Da) 82,244
Isoelectric Point (pI) 4.22
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:114664 to 112475 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -131 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2190 114664..112475 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003171
References cited on this page View Complete Literature Guide for KEX1
1) Bussey H, et al.  (1983) Secretion of Saccharomyces cerevisiae killer toxin: processing of the glycosylated precursor. Mol Cell Biol 3(8):1362-70
2) Cooper A and Bussey H  (1989) Characterization of the yeast KEX1 gene product: a carboxypeptidase involved in processing secreted precursor proteins. Mol Cell Biol 9(6):2706-14
3) Dmochowska A, et al.  (1987) Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and alpha-factor precursor processing. Cell 50(4):573-84
4) Carmona-Gutierrez D, et al.  (2013) The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast. Cell Cycle 12(11):1704-12